Biologic Effects of Interferons

Biologic effects of isohydroxyurea.

SUMMARY Isohydroxyurea causes a rapid devitalization of E. coli C600. The effect of this agent on bacterial metabolism is manifested mainly in an inhibition in the synthesis of RNA. This is in marked contrast to the biologic action of the isomeric com pound, hydroxyurea, which is primarily bacteriostatic in na ture and which involves a specific block in DNA production. The lethal action of isoh...

Differential Effects of the Type I Interferons

Effects of Interferons and Viruses on Metabolism

Interferons (IFNs) are potent pleiotropic cytokines that broadly alter cellular functions in response to viral and other infections. These alterations include changes in protein synthesis, proliferation, membrane composition, and the nutritional microenvironment. Recent evidence suggests that antiviral responses are supported by an IFN-induced rewiring of the cellular metabolism. In this review...

The Biologic Effects of Tobacco

This small volume consists essentially of six review articles and one essay. The first article, by Alvin I. Kosak, deals with the chemistry of tobacco smoke. This is a well-written and carefully documented section which emphasizes the need for more uniformity in experimental methods in the field and indicates a lack of knowledge in the important phase of aerosol retention. The chapter on pharma...

Biologic Effects of Laser Radiation

( )IR EXPERIMENTS were designed to determine the effects of focused and unfocused laser radiation upon the heads of animals. This report is the result of our first set of experiments. While preparing these experiments, Drs. Sam Fine and Edmund Klein told us of their unreported experiments in which they produced subarachnoid hemorrhage and death in mice within a few minutes by directing an unfoc...